2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W090292
    Olivetolic acid 491-72-5 99.82%
    Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity.
    Olivetolic acid
  • HY-W100209
    5Me3F4AP 13958-85-5 99.55%
    5Me3F4AP is a potent blocker of potassium channel, with the IC50 of 220 μM to 693 μM when the pH is increased from 6.4 to 9.1. 5Me3F4AP has the potential to cross the blood-brain barrier and potential application in positron emission tomography (PET).
    5Me3F4AP
  • HY-W100249
    MMAI 136468-19-4 99.08%
    MMAI is a selective serotonin releaser that can be used in the research of mental illnesses.
    MMAI
  • HY-W129359
    11β-HSD1-IN-8 386704-15-0
    11β-HSD1-IN-8 (compound c6a) is a 11β HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline.
    11β-HSD1-IN-8
  • HY-W141374
    CB096 108883-90-5 98.72%
    CB096 binds the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells.
    CB096
  • HY-W143890
    Etifenin 63245-28-3 99.74%
    Etifenin can be used for production of non-toxic radiopharmaceuticals which are in regular radiodiagnostic use.
    Etifenin
  • HY-W152604
    Cyclo(glycyl-L-leucyl) 5845-67-0 99.79%
    Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.
    Cyclo(glycyl-L-leucyl)
  • HY-W197713
    2-Amino-N-phenylpropanamide hydrochloride 153973-14-9 ≥99.0%
    2-Amino-N-phenylpropanamide (Compound 5b) hydrochloride is a Tocainid (HY-B1798) analog. Tocainid is an antiarrythmic agent.
    2-Amino-N-phenylpropanamide hydrochloride
  • HY-W224327
    Pheniprazine 55-52-7 98%
    Pheniprazine is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression.
    Pheniprazine
  • HY-W259888
    (R)-2-Hydroxysuccinic acid methyl ester 83540-94-7 98%
    (R)-2-Hydroxysuccinic acid methyl ester is a biochemical that can be used for the research of cancer or amyloidosis.
    (R)-2-Hydroxysuccinic acid methyl ester
  • HY-W294348
    Prenderol 115-76-4 99.85%
    Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity.
    Prenderol
  • HY-W355463
    3-Demethylthiocolchicine 87424-25-7 98%
    3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity.
    3-Demethylthiocolchicine
  • HY-W417914
    4-Methylamphetamine hydrochloride 41632-56-8 99.86%
    4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders.
    4-Methylamphetamine hydrochloride
  • HY-W745029
    L-Glutathione reduced-d5 98%
    L-Glutathione reduced-d5 (GSH-d5; γ-L-Glutamyl-L-cysteinyl-glycine-d5) is the deuterium labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
    L-Glutathione reduced-d5
  • HY-W750342
    Tryptophol-d4 75238-45-8 99.97%
    Tryptophol-d4 (Indole-3-ethanol-d4) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
    Tryptophol-d4
  • HY-W772850
    Fenclonine hydrochloride 23633-07-0 98%
    Fenclonine hydrochloride is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine hydrochloride can be used in carcinoid syndrome research.
    Fenclonine hydrochloride
  • HY-W775306
    Cannabidivarinic acid 31932-13-5 99.67%
    Cannabidivarinic acid (CBDVA), the carboxylic acid precursor of Cannabidivarin(CBDV), is a non-psychoactive cannabinoid found in Cannabis with anti-inflammatory properties.
    Cannabidivarinic acid
  • HY-Y0921S2
    (±)-1,2-Propanediol-d6 52910-80-2 ≥99.0%
    (±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d6
  • HY-100013B1
    (1S,2S)-2-PCCA hydrochloride 1609563-70-3 99.65%
    (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.
    (1S,2S)-2-PCCA hydrochloride
  • HY-103252S2
    Monomethyl fumarate-d2 253122-44-0 98.19%
    Monomethyl fumarate-d2 is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease.
    Monomethyl fumarate-d2
Cat. No. Product Name / Synonyms Application Reactivity